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Proses ini melibatkan sel-sel kekebalan tubuh yang disebut sel T. Sel T adalah tentara dalam tubuh yang bertanggung jawab untuk mengenali dan menghancurkan sel-sel yang terinfeksi. Vaksin BCG membantu sel T untuk “mengingat” bakteri TBC sehingga mereka dapat merespons dengan cepat dan efektif. Selain itu, vaksin BCG juga merangsang produksi antibodi, yaitu protein yang membantu tubuh melawan infeksi. Antibodi ini akan mengikat bakteri TBC dan membantu tubuh untuk menghancurkannya. **Efek perlindungan dari vaksin BCG** tidak bertahan seumur hidup. Perlindungan ini biasanya bertahan selama 10-20 tahun. Itulah sebabnya, vaksin BCG sangat penting diberikan pada bayi, saat mereka paling rentan terhadap penyakit TBC.
