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Ada beberapa penyebab eosinopenia. **Stres fisik atau emosional** dapat menyebabkan penurunan jumlah eosinofil. Ketika tubuh mengalami stres, hormon kortisol dilepaskan, yang dapat menekan produksi eosinofil. **Penggunaan obat-obatan tertentu** seperti kortikosteroid juga dapat menyebabkan eosinopenia. Kortikosteroid memiliki efek anti-inflamasi yang dapat menekan aktivitas sistem kekebalan tubuh, termasuk produksi eosinofil. **Infeksi berat** seperti infeksi bakteri atau virus juga dapat menyebabkan eosinopenia. Ketika tubuh melawan infeksi, sistem kekebalan tubuh mungkin memprioritaskan produksi sel-sel imun lainnya, sehingga produksi eosinofil menurun. **Sindrom Cushing** adalah kondisi di mana tubuh memproduksi terlalu banyak hormon kortisol. Kelebihan kortisol dapat menyebabkan penurunan jumlah eosinofil. **Beberapa kondisi medis lainnya** seperti leukemia juga dapat menyebabkan eosinopenia.
