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Before we jump into the vaccine, let's get a grip on what TNBC actually is. Most breast cancers have receptors for estrogen, progesterone, or HER2. These receptors act like docking stations for hormones or growth factors, which fuel cancer growth. TNBC, however, lacks all three of these receptors – hence the name "triple-negative." This absence makes it resistant to hormonal therapies and drugs that target HER2, leaving chemotherapy as the main treatment option.
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